Event Calendar

PETACH TIKVA, Israel, April 13, 2026 (GLOBE NEWSWIRE) -- PolyPid Ltd. (Nasdaq: PYPD) (“PolyPid” or the “Company”), an innovative biopharmaceutical company dedicated to improving patient outcomes by elevating treatment effectiveness, right where care begins, today announced that the Company will present new pharmacokinetic data from the Phase 3 SHIELD II trial evaluating D-PLEX₁₀₀ at the Congress of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Global 2026 (formerly known as ECCMID), the world’s leading congress for clinical microbiology and infectious diseases, taking place on April 17-21, 2026, in Munich, Germany.

The abstract titled “Pharmacokinetics of local extended-release incisional doxycycline in patients undergoing abdominal colorectal surgery from the SHIELD II Phase 3 clinical trial,” was co-authored by Prof. Antonino Spinelli, Director of the Division of Colon and Rectal Surgery and a Professor of Surgery at Humanitas University, in Milan, Italy and PolyPid.

Key findings from the SHIELD II analysis:

• Sustained and controlled release profile: Detectable doxycycline concentrations were observed for up to 763 hours (approximately 32 days), with no burst, following local application of D-PLEX₁₀₀ during surgery.
  
  
   

Figure 1. Mean (+ standard deviation) plasma doxycycline concentration versus time profile

• Minimal systemic exposure: Plasma doxycycline concentrations remained below 100 ng/mL, indicating negligible systemic levels relative to oral doxycycline administration where C_max levels are approximately 16 to 26 times higher (1,613.3 ng/mL for 100 mg¹ and 2,600 ng/mL for 200 mg² doses).
  
   

“These pharmacokinetic results further support the mechanism of D-PLEX₁₀₀, which is designed to deliver sustained and controlled antibiotic exposure for 30 days directly at the surgical incision site,” said Dikla Czaczkes Akselbrad, Chief Executive Officer of PolyPid. “The findings reinforce the potential of D-PLEX₁₀₀ to address a key limitation of conventional systemic prophylactic antibiotics by maintaining local antimicrobial activity during the critical 30 days post-surgical period when infections most commonly develop.”

ESCMID Global 2026 Presentation Details