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  <xs:element id="pypd_ShareholdersEquityDetailsTable" name="ShareholdersEquityDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="pypd_PreFundedWarrantsMember" name="PreFundedWarrantsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="pypd_ScheduleOfDilutedNetLossPerShareAttributableToOrdinaryShareholdersAbstract" name="ScheduleOfDilutedNetLossPerShareAttributableToOrdinaryShareholdersAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="pypd_April2022Member" name="April2022Member" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="pypd_December2024WarrantsMember" name="December2024WarrantsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="pypd_NewWarrantsSharesMember" name="NewWarrantsSharesMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="pypd_OfficersMember" name="OfficersMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="pypd_ScheduleOfOptionsToEmployeesUnderTheCompanySOptionPlanAbstract" name="ScheduleOfOptionsToEmployeesUnderTheCompanySOptionPlanAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="pypd_ProceedsFromParticipationPayments" name="ProceedsFromParticipationPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="pypd_PercentageOfGrantReceived" name="PercentageOfGrantReceived" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="pypd_DefinitiveSecuritiesPurchaseAgreementMember" name="DefinitiveSecuritiesPurchaseAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xs:schema>
